Population
Rat calvarial cells (osteoblasts)
Comparison
Fluid shear stress (6 dyn/cm2) vs Stationary culture
Design
Preclinical
Follow-up
12 h
Authors
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Fluid shear stress may drive sustained osteoblast NO release; leaves open its role in bone remodeling pending in vivo confirmation.
Fluid flow is a potent stimulus for nitric oxide release in osteoblasts, suggesting a primary role in bone maintenance and remodeling.
Johnson et al. (1996) studied this question.
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