Ventricular tachycardia ablation in a patient with Ehlers-Danlos syndrome

Key Teaching Points•When performing endovascular procedures, all comorbidities should be considered in terms of risk vs benefit to the patient. This may include rare conditions such as Ehlers-Danlos syndrome or other connective tissue disorders, which may affect vascular stability, risk of bleeding, and wound healing.•A stepwise approach to intervention in such patients is advised, as detailed in our manuscript. This should include thorough imaging, multidisciplinary team discussion, and a careful, individualized consent process.•Ventricular tachycardia ablation can be highly effective at suppressing scar-related life-threatening arrhythmia and can be safely undertaken in those with mild connective tissue disease, such as our patient. More severe disease may require more a more conservative approach. •When performing endovascular procedures, all comorbidities should be considered in terms of risk vs benefit to the patient. This may include rare conditions such as Ehlers-Danlos syndrome or other connective tissue disorders, which may affect vascular stability, risk of bleeding, and wound healing.•A stepwise approach to intervention in such patients is advised, as detailed in our manuscript. This should include thorough imaging, multidisciplinary team discussion, and a careful, individualized consent process.•Ventricular tachycardia ablation can be highly effective at suppressing scar-related life-threatening arrhythmia and can be safely undertaken in those with mild connective tissue disease, such as our patient. More severe disease may require more a more conservative approach.