What does this research mean for the field?

Concentric left ventricular hypertrophy (cLVH) present at the initiation of peritoneal dialysis is an independent risk factor for mortality in all patients, and for both mortality and major adverse cardiovascular events (MACE) in elderly patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 16, 2021BMC NephrologyOpen Access

Prognostic significance of concentric left ventricular hypertrophy at peritoneal dialysis initiation

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Why the study?

The relationship between concentric left ventricular hypertrophy (cLVH) at peritoneal dialysis (PD) initiation and patient prognosis remained unclear.

Does concentric left ventricular hypertrophy at peritoneal dialysis initiation predict mortality and MACE in adult patients?

Population

131 patients undergoing echocardiography during the PD initiation period

Comparison

cLVH vs non-cLVH at PD initiation

Design

Retrospective cohort study

Authors

MTMisato TomuraUniversity of Tokyo Hospital YHYoshifumi HamasakiUniversity of Tokyo Hospital YKYohei KomaruUniversity of Tokyo Hospital

Discussion

Member takes

Implication

cLVH at PD initiation was associated with mortality; hypothesis-generating and requires prospective validation before guiding risk stratification.

Structured PICO

Does concentric left ventricular hypertrophy at peritoneal dialysis initiation predict mortality and MACE in adult patients?

Population

131 adult patients who started peritoneal dialysis (PD) therapy as their first renal replacement therapy between 2001 and 2018, mean age 60.8, 74% male, single center (The University of Tokyo Hospital, Japan).

Intervention

Concentric left ventricular hypertrophy (cLVH) at PD initiation (defined as LVMI > 115 g/m2 for males and > 95 g/m2 for females, combined with RWT > 0.42)

Comparator

Non-cLVH at PD initiation

Outcome

All-cause mortality until six months after PD cessationhard clinical

Concentric left ventricular hypertrophy at peritoneal dialysis initiation is an independent predictor of all-cause mortality and major adverse cardiovascular events.

Limitations

Single-institution-based
Small sample sizes
Small number of events
Most patients were treated using automated PD

Cite This Study

Tomura et al. (2021) studied this question.

synapsesocial.com/papers/6a1d2250ba65f5ee325ddce8 https://doi.org/10.1186/s12882-021-02321-1

Topics

Women and heart disease Echocardiography Sermorelin

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Implication

cLVH at PD initiation was associated with mortality; hypothesis-generating and requires prospective validation before guiding risk stratification.

Prognostic significance of concentric left ventricular hypertrophy at peritoneal dialysis initiation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Prognostic significance of concentric left ventricular hypertrophy at peritoneal dialysis initiation

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider