Key result
Left ventricular hypertrophy, whether eccentric or concentric, was associated with a shorter time to cardiovascular events compared to normal geometry in CAPD patients.
Why the study?
Does the geometric pattern of left ventricular hypertrophy (eccentric or concentric) predict cardiovascular events in continuous ambulatory peritoneal dialysis patients?
Observational (n=65)
No
Does the geometric pattern of left ventricular hypertrophy (eccentric or concentric) predict cardiovascular events in continuous ambulatory peritoneal dialysis patients?
Answers are grounded in this paper and cite their sources.
In continuous ambulatory peritoneal dialysis patients, both eccentric and concentric left ventricular hypertrophy are strong predictors of poor cardiovascular prognosis and shorter event-free survival.
Objective: Left ventricular hypertrophy (LVH) is highly predictive of cardiovascular (CV) events in dialysis patients. The impact of different left ventricular (LV) geometric patterns on cardiovascular outcome has not been well established. The aim of this prospective observational study was to define the patterns of LVH and find out their impact on future cardiovascular events in patients on continuous ambulatory peritoneal dialysis (CAPD). Material and Methods: Patients were followed up between 1999 and 2006 for cardiovascular events. Left ventricular mass and geometric patterns were determined by echocardiography. Kaplan-Meier method and Cox regression analysis were used to evaluate the impact of LV geometric patterns on CV event free survival. Results: Sixty-five CAPD patients were enrolled in the study and were followed for 76 ± 15 months. There were a total of 16 (14 fatal, two non-fatal) CV events. Mean event-free survival time for patients without LVH was 79 ± 3 months (95% CI of 73 to 86 months). The mean CV event-free survival for the patients with concentric LV hypertrophy and eccentric hypertrophy was 75 ± 3 months (95% CI of 69 to 81 months), and 76 ± 3 months (95% CI of 69 to 82 months) respectively. Patients with eccentric [hazard ratio (HR): 20.2] and concentric (HR:18.7) LV hypertrophy had shorter time to CV event when compared to the patients without LV hypertrophy (p= 0.042). Conclusion: Left ventricular hypertrophy is a marker of poor cardiovascular prognosis irrespective of its pattern. Both eccentric and concentric LV hypertrophy are associated with shorter CV event- free survival compared to normal geometry and concentric remodeling.
No takes yet. Share an insight, caveat, or question.
Tezcan et al. (2011) conducted an observational in End-stage renal disease on continuous ambulatory peritoneal dialysis (n=65). Left ventricular hypertrophy (eccentric and concentric) vs. Normal geometry and concentric remodeling (no LVH) was evaluated on Time to cardiovascular event (HR 19.4, 95% CI 1.3-295, p=0.033). Left ventricular hypertrophy, whether eccentric or concentric, was associated with a shorter time to cardiovascular events compared to normal geometry in CAPD patients.
Synapse has enriched 10 related papers. Consider them for comparative context: