Aging is driven by oxidative damage to DNA, proteins, and lipids. Oxidative stress from an imbalance between reactive oxygen species and antioxidant defenses accelerates age-related decline. Dietary antioxidants—vitamins C and E, carotenoids, selenium, and polyphenols—neutralize free radicals and activate the Nrf2 pathway. This review synthesizes evidence from observational cohorts, randomized trials, and biomarker studies on antioxidant-rich whole foods for healthy aging. Large prospective studies show that high intake of fruits, vegetables, nuts, and whole grains is associated with longer telomeres, reduced oxidative DNA damage, and lower all-cause mortality. Conversely, high-dose single antioxidant supplements fail to show benefits and may cause harm. Practical dietary strategies—including the Mediterranean diet and daily consumption of specific vegetarian and non-vegetarian antioxidant-rich foods—offer safe, effective approaches to extend healthspan. Public health recommendations should prioritize whole foods over supplements.
Mrs. Priyanka Laxmikant Lakal* (Mon,) studied this question.