Caffeine Induces Ventricular Tachyarrhythmias Possibly Due to Triggered Activity in Rabbits in Vivo
Why the study?
Does caffeine infusion induce ventricular tachyarrhythmias in rabbits in vivo?
Population
Rabbits in vivo
Comparison
Continuous infusion of caffeine at doses of 0.3… vs Lower dose caffeine or baseline
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Caffeine-associated VT in rabbits warrants no clinical changes; extends isolated tissue DAD findings to an in vivo model.
Structured PICO
Does caffeine infusion induce ventricular tachyarrhythmias in rabbits in vivo?
P
Population
Rabbits in vivo
I
Intervention
Continuous infusion of caffeine at doses of 0.3 or 1.0 mg/kg per min, combined with ventricular pacing
C
Comparator
Lower dose caffeine (0.3 mg/kg per min) or baseline
O
Outcome
Induction of ventricular tachycardia (VT)surrogate
Caffeine induces ventricular tachycardia in an in vivo rabbit model, likely mediated by catecholamine-associated triggered activity.
Cite This Study
Ishida et al. (1996) studied this question.