Key result
Caffeine (1 mM) increased the frequency of ventricular tachycardia from 0% to 100% in isolated intact mouse hearts, an effect suppressed by diltiazem but not nifedipine.
Population
Isolated intact mouse hearts and isolated mouse ventricular cells
Comparison
Caffeine with or without pretreatment with… vs Baseline and nifedipine pretreatment
Design
Preclinical
Authors
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Caffeine may heighten arrhythmia risk in HF; leaves open ryanodine receptor targeting in clinical settings.
Absolute Event Rate: 100% vs 0%
Spontaneous sarcoplasmic reticular Ca2+ waves are directly implicated in triggered arrhythmogenesis in intact murine hearts, as demonstrated by caffeine-induced ventricular tachycardia that is suppressible by diltiazem.
Balasubramaniam et al. (2005) studied Ventricular arrhythmogenesis. Caffeine vs. Baseline/control was evaluated on Frequency of ventricular tachycardia during programmed electrical stimulation. Caffeine (1 mM) increased the frequency of ventricular tachycardia from 0% to 100% in isolated intact mouse hearts, an effect suppressed by diltiazem but not nifedipine.
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