CC Chemokine Receptor 2 Is Required for Macrophage Infiltration and Vascular Hypertrophy in Angiotensin II–Induced Hypertension
Why the study?
Does CCR2 deficiency reduce macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension in mice?
Population
Mice deficient in CC chemokine receptor 2 (CCR2) and wild-type mice
Comparison
Subcutaneous administration of angiotensin II… vs Wild-type mice receiving the same angiotensin II…
Design
Preclinical
Follow-up
7 days
Authors
Discussion
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Member takes
Implication
CCR2 mediates macrophage-driven vascular hypertrophy in hypertensive mice; hypothesis-generating and should not yet change practice.
Structured PICO
Does CCR2 deficiency reduce macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension in mice?
P
Population
Mice deficient in CC chemokine receptor 2 (CCR2) and wild-type mice
I
Intervention
Subcutaneous administration of angiotensin II (0.75 mg/kg/d) for 7 days
C
Comparator
Wild-type mice receiving the same angiotensin II treatment
O
Outcome
Macrophage infiltration of the arterial wall and vascular hypertrophysurrogate
CCR2 is essential for macrophage recruitment and vascular hypertrophy in angiotensin II-induced hypertension, highlighting a potential mechanism linking hypertension to atherosclerosis.
Cite This Study
Bush et al. (2000) studied this question.