Why the study?
Does melatonin supplementation reduce blood pressure reactivity or nighttime blood pressure in healthy normotensive adults on a high-sodium diet?
Does melatonin supplementation reduce blood pressure reactivity or nighttime blood pressure in healthy normotensive adults on a high-sodium diet?
Melatonin supplementation for 10 days reduces nighttime peripheral and central systolic blood pressure in healthy normotensive adults on a high-sodium diet, though it does not affect BP reactivity.
Melatonin may lower nighttime systolic BP on high-sodium diets; leaves open any role in BP management pending larger trials.
BP reactivity was assessed during isometric handgrip (IHG) exercise, postexercise ischemia (PEI), and the cold pressor test (CPT) after 10 days of a high-sodium diet with and without melatonin supplementation. Melatonin did not alter BP reactivity in healthy normotensive men and women. However, melatonin did decrease nighttime peripheral and central systolic BP, suggesting it may be beneficial in lowering BP even in those with a normal BP.
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Gonzalez et al. (2023) studied this question.
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