Why the study?
Does intense lower body negative pressure disrupt MSNA firing characteristics and dissociate arterial pressure from sympathetic traffic prior to presyncope in healthy volunteers?
Population
17 healthy volunteers (12 males and 5 females)
Comparison
Lower body negative pressure applied in 5-minute… vs Baseline (0% of maximal tolerance)
Design
Other
Authors
Loading...
MSNA withdrawal not required for presyncope; leaves open baroreflex dissociation mechanisms in clinical syncope populations.
Does intense lower body negative pressure disrupt MSNA firing characteristics and dissociate arterial pressure from sympathetic traffic prior to presyncope in healthy volunteers?
Intense lower body negative pressure increases coherence between arterial pressure and MSNA, but sympathetic baroreflex control is reduced before presyncope, and MSNA withdrawal is not a prerequisite for presyncope.
Cooke et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: