Why the study?
Age-related changes in phase synchronization of spontaneous mean arterial pressure and heart rate fluctuations within the baroreflex wave range during orthostatic stress were not fully understood.
Does age affect the phase synchronization of mean arterial pressure and heart rate during orthostatic stress?
Does age affect the phase synchronization of mean arterial pressure and heart rate during orthostatic stress?
Age over 40 is associated with a decreased baroreflex response to orthostatic stress, as measured by the phase synchronization of blood pressure and heart rate.
Age >40 associated with blunted PSI response to orthostasis; hypothesis-generating for baroreflex decline and requires longitudinal confirmation.
Age-related changes in phase synchronization of spontaneous mean arterial pressure (MAP) and heart rate (HR) fluctuations within the baroreflex wave range (around 0.1 Hz) were studied in 66 subjects aged 20 to 52 years. During the head-up tilt test, MAP (photocompensation method), ECG (to calculate heart rate), and respiratory rate were continuously recorded. To quantify MAP–HR coupling, the phase synchronization index (PSI) was used. In people over 40 years, an increase in phase synchronization of MAP and HR was found in a supine position compared with subjects aged 20–24 years. At the same time, the increase in PSI of MAP and HR in response to orthostatic stress decreased after the age of 40, which may reflect a decrease in baroreflex activity with age.
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Орлова et al. (2022) studied this question.
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