Why the study?
Does cancer treatment (anthracyclines and radiotherapy) increase long-term overall and cardiovascular mortality in 5-year survivors of childhood cancer?
Population
4,122 5-year survivors of a childhood cancer diagnosed before 1986 in France and the United Kingdom
Comparison
Cancer treatment including chemotherapy and… vs General populations in France and the United…
Design
Cohort
Follow-up
average, 27 years
Authors
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Supports minimizing anthracycline and cardiac radiation doses in childhood cancer; leaves open prospective validation of mortality thresholds.
Does cancer treatment (anthracyclines and radiotherapy) increase long-term overall and cardiovascular mortality in 5-year survivors of childhood cancer?
High cumulative doses of anthracyclines and radiation to the heart during childhood cancer treatment are associated with a significantly increased risk of long-term cardiac mortality.
Tukenova et al. (2010) studied this question.
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