Why the study?
How does hypothermic cardiopulmonary bypass affect the oxyhemoglobin dissociation curve (P50) in patients undergoing cardiac surgery?
Population
15 patients subjected to hypothermic cardiopulmonary bypass under opiate-benzodiazepine anesthesia
Comparison
Hypothermic cardiopulmonary bypass using the… vs Pre-anesthesia baseline and post-bypass…
Design
Cohort
Follow-up
8 hours after cardiopulmonary bypass
Authors
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May impair oxygen unloading during hypothermic CPB; hypothesis-generating for oxygenation strategies in cardiac surgery.
How does hypothermic cardiopulmonary bypass affect the oxyhemoglobin dissociation curve (P50) in patients undergoing cardiac surgery?
Hypothermic cardiopulmonary bypass causes a significant leftward shift in the oxyhemoglobin dissociation curve, which may impair cellular oxygen delivery despite adequate venous oxygen saturation.
Coetzee et al. (1990) studied this question.
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