Why the study?
Does maintaining non-temperature-corrected PaCO2 at 40 mm Hg compared to temperature-corrected PaCO2 improve cerebral blood flow regulation and flow/metabolism coupling in patients undergoing hypothermic cardiopulmonary bypass?
Population
38 patients undergoing hypothermic nonpulsatile cardiopulmonary bypass at 26 degrees C
Comparison
Maintaining non-temperature-corrected PaCO2 at… vs Maintaining temperature-corrected PaCO2 at 40 mm…
Design
Cohort
Follow-up
During cardiopulmonary bypass
Authors
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Non-temperature-corrected PaCO2 was associated with preserved CBF regulation during hypothermic bypass; hypothesis-generating and requires randomized confirmation before practice change.
Does maintaining non-temperature-corrected PaCO2 at 40 mm Hg compared to temperature-corrected PaCO2 improve cerebral blood flow regulation and flow/metabolism coupling in patients undergoing hypothermic cardiopulmonary bypass?
Maintaining non-temperature-corrected PaCO2 at 40 mm Hg during hypothermic cardiopulmonary bypass better preserves cerebral autoregulation and flow/metabolism coupling compared to temperature-corrected PaCO2.
Murkin et al. (1987) studied this question.
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