What question did this study set out to answer?

To determine how arterial pressure, systemic pump flow, arterial carbon dioxide tension, temperature, and hemoglobin influence regional cerebral blood flow during hypothermic nonpulsatile cardiopulmonary bypass.

February 12, 2019Anesthesiology

Toward Understanding Cerebral Blood Flow during Cardiopulmonary Bypass

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Why the study?

The study examined the relationship of regional cerebral blood flow to mean arterial pressure, systemic blood flow, PaCO2, nasopharyngeal temperature, and hemoglobin during hypothermic nonpulsatile CPB.

What factors influence regional cerebral blood flow during hypothermic nonpulsatile cardiopulmonary bypass in patients undergoing coronary bypass grafting?

Population

67 patients undergoing coronary bypass grafting procedures

Authors

JRJ. G. RêvesCardiac Surgery

Discussion

Member takes

Implication

Temperature and PaCO2 may guide CBF management during CPB; leaves open effects on neurologic outcomes.

Key Points

To determine how arterial pressure, systemic pump flow, arterial carbon dioxide tension, temperature, and hemoglobin influence regional cerebral blood flow during hypothermic nonpulsatile cardiopulmonary bypass.
Assessed 67 patients undergoing coronary artery bypass grafting under hypothermic nonpulsatile cardiopulmonary bypass.
Measured regional cerebral blood flow using xenon 133 clearance, evaluating a 10-patient subgroup across pump flow rates adjusted between 1.0 and 2.0 L/min/m2.
Regional cerebral blood flow decreased by 55% during cardiopulmonary bypass, with nasopharyngeal temperature and PaCO2 acting as the only significant determinants (p < 0.05).
Variations in pump flow between 1.0 and 2.0 L/min/m2 in the 10-patient subgroup did not significantly alter regional cerebral blood flow, confirming that cerebral autoregulation is maintained.

Structured PICO

What factors influence regional cerebral blood flow during hypothermic nonpulsatile cardiopulmonary bypass in patients undergoing coronary bypass grafting?

Population

67 patients undergoing coronary bypass grafting procedures

Intervention

Hypothermic nonpulsatile cardiopulmonary bypass (CPB)

Outcome

Regional cerebral blood flow (CBF) determined by clearance of xenon 133surrogate

Cerebral autoregulation is retained during hypothermic cardiopulmonary bypass, and variations in flow and pressure under usual conditions do not cause detrimental clinical effects.

Cite This Study

J. G. Rêves (2019) studied this question.

synapsesocial.com/papers/6a8876748c7e900eb714d567 https://doi.org/10.1097/aln.0000000000002580

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Toward Understanding Cerebral Blood Flow during Cardiopulmonary Bypass

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Toward Understanding Cerebral Blood Flow during Cardiopulmonary Bypass

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider