Why the study?
What are the determinants of cerebral blood flow and their clinical implications during hypothermic cardiopulmonary bypass in patients undergoing coronary artery surgery?
Population
58 patients undergoing elective coronary artery surgery (CABS)
Comparison
Hypothermic cardiopulmonary bypass using a 'pH… vs Prebypass and postbypass physiological states
Design
Cohort
Follow-up
Perioperative (prior to, during, and following bypass)
Authors
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Observational data link pH-stat to cerebral hyperperfusion during bypass; leaves open whether alphastat better matches supply-demand in coronary surgery.
What are the determinants of cerebral blood flow and their clinical implications during hypothermic cardiopulmonary bypass in patients undergoing coronary artery surgery?
The use of a 'pH stat' protocol during hypothermic cardiopulmonary bypass results in relative cerebral hyperperfusion, suggesting that an 'alphastat' protocol might better match cerebral blood flow to demand and potentially reduce microembolic cerebral damage.
Venn et al. (1988) studied this question.
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