Key result
An inspired oxygen fraction of 0.35 increased to 0.45 during rewarming reduced hyperoxemia episodes to 30%, compared to 100% and 88% with higher oxygen settings.
Why the study?
Does a lower inspired oxygen fraction (0.35 increased to 0.45) reduce the incidence of hyperoxemia during cardiopulmonary bypass in patients undergoing isolated CABG compared to higher oxygen fractions?
Population
90 patients undergoing isolated coronary artery bypass operations
Comparison
Inspired oxygen fraction of 0.35 during… vs FiO2 of 0.40 increased to 0.60 during rewarming…
Design
RCT, randomly allocated to one of 3 groups
Follow-up
during the operation
Authors
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Supports conservative FiO2 during CPB in CABG; extends RCT evidence for optimized intraoperative oxygen management.
RCT (n=90)
randomly allocated
Does a lower inspired oxygen fraction (0.35 increased to 0.45) reduce the incidence of hyperoxemia during cardiopulmonary bypass in patients undergoing isolated CABG compared to higher oxygen fractions?
Absolute Event Rate: 30% vs 100%
p-value: p=significant
Setting the inspired oxygen fraction to 0.35 during cardiopulmonary bypass and 0.45 during rewarming significantly reduces the incidence of intraoperative hyperoxemia compared to higher oxygen settings.
Toraman et al. (2007) conducted an RCT in isolated coronary artery bypass operations (n=90). Inspired oxygen fraction of 0.35, increased to 0.45 during rewarming vs. Inspired oxygen fraction of 0.40, increased to 0.50 or 0.60 was evaluated on At least one episode of hyperoxemia during cardiopulmonary bypass (p=significant). An inspired oxygen fraction of 0.35 increased to 0.45 during rewarming reduced hyperoxemia episodes to 30%, compared to 100% and 88% with higher oxygen settings.