Key result
Adjusting the fraction of inspired oxygen to 0.35-0.45 during cardiopulmonary bypass reduced hyperoxemia incidence to 22.8% compared to 42.8% with higher fractions, while hypoxia occurred in 14% of the lower fraction group.
Why the study?
Does adjusting FiO2 to 0.35-0.45 compared to 0.40-0.50 affect the incidence of cerebral hypoxia or hyperoxemia during CABG?
Population
70 patients with coronary heart disease scheduled for coronary artery bypass graft surgery. Group 1: mean…
Comparison
Adjusted inspired oxygen fraction at 0.35-0.45… vs Adjusted inspired oxygen fraction at 0.40-0.50…
Design
Cohort
Follow-up
During CABG surgery (5 measurement periods)
Authors
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NIRS-guided FiO2 0.35-0.45 was associated with lower hyperoxemia during CPB; hypothesis-generating for cerebral oxygenation targets pending randomized trials.
RCT (n=70)
No
Does adjusting FiO2 to 0.35-0.45 compared to 0.40-0.50 affect the incidence of cerebral hypoxia or hyperoxemia during CABG?
Absolute Event Rate: 14% vs 0%
NIRS monitoring during CABG allows for the detection of cerebral hypoxia and hyperoxemia, guiding appropriate FiO2 adjustments to optimize cerebral perfusion.
Fevzı Toraman (2013) conducted an RCT in Coronary heart disease (n=70). Lower fraction of inspired oxygen (FiO2) vs. Higher fraction of inspired oxygen (FiO2 0.40-0.50) was evaluated on Incidence of hypoxia (pO2 < 80 mmHg). Adjusting the fraction of inspired oxygen to 0.35-0.45 during cardiopulmonary bypass reduced hyperoxemia incidence to 22.8% compared to 42.8% with higher fractions, while hypoxia occurred in 14% of the lower fraction group.
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