Why the study?
Does OPC-18790 improve inotropic, lusitropic, and vascular parameters in patients with dilated cardiomyopathy?
Population
17 patients with dilated cardiomyopathy and congestive heart failure
Comparison
OPC-18790 by 1-hour IV infusion at 5… vs Baseline measurements (pre-infusion)
Design
Cohort
Follow-up
1 hour
Authors
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Supports hemodynamic effects of OPC-18790 in dilated cardiomyopathy; hypothesis-generating and requires randomized trials before practice consideration.
Does OPC-18790 improve inotropic, lusitropic, and vascular parameters in patients with dilated cardiomyopathy?
OPC-18790 demonstrates potent venous and arterial vasodilator effects along with moderate inotropic and lusitropic effects in patients with dilated cardiomyopathy.
Feldman et al. (1996) studied this question.
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