February 15, 1996Circulation

Mechanism of Action of OPC-8490 in Human Ventricular Myocardium

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AFAmelia FocaccioClinica Mediterranea GPG PeetersGhent University MMMatthew A. MovsesianIntermountain Healthcare

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Implication

OPC-8490's PDE-III plus ion channel effects merit further mechanistic dissection; leaves open safe translation of quinolinones to heart failure therapy.

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Focaccio et al. (1996) studied this question.

synapsesocial.com/papers/6a209584adeb32760d598286 https://doi.org/10.1161/01.cir.93.4.817

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HFrEF treatment Heart failure

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Implication

OPC-8490's PDE-III plus ion channel effects merit further mechanistic dissection; leaves open safe translation of quinolinones to heart failure therapy.

Mechanism of Action of OPC-8490 in Human Ventricular Myocardium

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Mechanism of Action of OPC-8490 in Human Ventricular Myocardium

Discussion

Member takes

Implication

Key Points

Cite This Study

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