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July 1, 1987Journal of Cardiovascular Pharmacology

Antitachycardiac Effect of OPC-8212, a Novel Cardiotonic Agent, on Tachycardiac Responses of Guinea Pig Isolated Right Atria to Isoproterenol and Histamine

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Authors

TYTeruyuki YanagisawaTohoku University KIKuniaki IshiiYamagata University NTNorio TairaTohoku University

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Implication

Does not support clinical use for rate control; leaves open whether this defines a novel selective chronotropic mechanism.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Yanagisawa et al. (1987) studied this question.

synapsesocial.com/papers/6a88040bf1be703dfaf4c685 https://doi.org/10.1097/00005344-198707000-00007

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.1989 · 3 citations
2Sustained inotropic effects of a new cardiotonic agent. OPC‐8212 in patients with chronic heart failure1989 · 26 citations
3Cardiac Electrophysiologic Action of Carteolol Hydrochloride (OPC‐1085), a New Beta‐Adrenergic Blocking Agent*1978 · 2 citations
4Effects of OPC-18790, a New Positive Inotropic Agent, on Canine Ventricular Arrhythmias1993 · 16 citations
5Mechanism of Action of OPC-8490 in Human Ventricular Myocardium1996 · 10 citations