Key result
In isolated animal heart preparations, carteolol hydrochloride demonstrated beta-blocking and potential beta-stimulating actions at lower concentrations, and direct membrane depression at high doses.
Why the study?
Does carteolol hydrochloride alter cardiac electrophysiologic properties in isolated animal heart preparations?
Population
Isolated, perfused rabbit hearts or atrial, ventricular, or Purkinje fibers of dogs and rabbits
Comparison
Carteolol hydrochloride at concentrations… vs Propranolol or baseline/control
Design
Preclinical
Authors
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Carteolol's dose-dependent effects in animal hearts warrant preclinical caution; leaves open human electrophysiologic translation.
Does carteolol hydrochloride alter cardiac electrophysiologic properties in isolated animal heart preparations?
Carteolol hydrochloride exhibits beta-blocking antiarrhythmic effects at clinical doses, with potential beta-stimulating action at higher concentrations and direct membrane depression at toxic levels.
Watanabe et al. (1978) studied this question. Carteolol hydrochloride (OPC-1085) vs. Propranolol was evaluated on Cardiac electrophysiologic action (transmembrane potentials and atrioventricular conduction). In isolated animal heart preparations, carteolol hydrochloride demonstrated beta-blocking and potential beta-stimulating actions at lower concentrations, and direct membrane depression at high doses.
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