January 1, 1989Japanese Heart JournalOpen Access

Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.

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Population

Isolated, blood-perfused canine heart preparations and intact support dogs

Design

Preclinical

Authors

YFYasuyuki FurukawaNational Institute of Advanced Industrial Science and Technology KAKunio AkahaneShinshu University MHMasayuki HaniudaAichi Medical University

Discussion

Member takes

Implication

No immediate clinical implications from canine data; leaves open translation of OPC-8490 mechanisms to human HF trials.

Structured PICO

Population

Isolated, blood-perfused canine heart preparations (right atria, left ventricular muscle) and intact support dogs

Intervention

OPC-8490 (0.1-1 mumol/kg IV in intact dogs; 10-3000 nmol in isolated preparations)

Outcome

Inotropic and chronotropic responses (heart rate, arterial blood pressure, contractile force)surrogate

OPC-8490 acts as a cardiotonic agent with positive inotropic and negative chronotropic effects mediated through multiple cellular mechanisms in the canine heart.

Cite This Study

Furukawa et al. (1989) studied this question.

synapsesocial.com/papers/6a7595fdf1e99ff85ab1fbd2 https://doi.org/10.1536/ihj.30.387

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Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider