What does this research mean for the field?

Quick releases deactivate muscle contraction by uncoupling crossbridges, a process that can be mitigated or reversed if sufficient calcium remains available to activate contractile sites. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1974Circulation ResearchOpen Access

Deactivation of Contraction by Quick Releases in the Isolated Papillary Muscle of the Cat

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Population

Isolated cat papillary muscle

Comparison

Quick releases and physiological/pharmacological… vs Isometric contraction or different modes of…

Design

Preclinical

Authors

RBR BodemBrigham and Women's Hospital ESEdmund H. SonnenblickUniversity of Parma

Discussion

Member takes

Implication

Should not yet change practice; hypothesis-generating for calcium modulation of load-dependent deactivation in myocardium.

Structured PICO

Population

Isolated cat papillary muscle

Intervention

Quick releases (undamped, damped, varying afterloads) and physiological/pharmacological modifications (tetanization, lowered temperature, 10 mM caffeine, increased Ca2+ concentration)

Comparator

Isometric contraction or different modes of quick release

Outcome

Time course of activation measured using instantaneous velocity of shorteningsurrogate

Quick releases deactivate contraction in isolated cat papillary muscles by uncoupling crossbridges, a process that can be mitigated if available calcium is not sequestered.

Cite This Study

Bodem et al. (1974) studied this question.

synapsesocial.com/papers/6a1d40dc28423f2ce504ebdd https://doi.org/10.1161/01.res.34.2.214

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Deactivation of Contraction by Quick Releases in the Isolated Papillary Muscle of the Cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deactivation of Contraction by Quick Releases in the Isolated Papillary Muscle of the Cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider