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August 1, 1980Acta Physiologica Scandinavica

Effects of phasic and tonic activation on contraction dynamics in smooth muscle

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Why the study?

Does AC-stimulation compared to K+-high medium alter contraction dynamics in smooth muscle preparations?

Population

Rabbit urinary bladder strips and rat portal veins

Comparison

AC-stimulation (phasic activation) vs K+-high medium (tonic activation)

Design

Preclinical

Authors

BUBengt UveliusLund UniversityPHPer HellstrandLund University

Discussion

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Implication

May guide stimulation protocols in smooth muscle experiments; leaves open translation to human physiology or clinical relevance.

Structured PICO

Does AC-stimulation compared to K+-high medium alter contraction dynamics in smooth muscle preparations?

P
Population
Rabbit urinary bladder strips and rat portal veins
I
Intervention
AC-stimulation (phasic activation)
C
Comparator
K+-high medium (tonic activation)
O
Outcome
Contraction dynamics (elastic recoil, isotonic transient, steady shortening velocity)surrogate

Phasic activation by AC-stimulation results in a higher steady shortening velocity compared to tonic activation by K+-high medium in smooth muscle preparations.

Cite This Study

Uvelius et al. (1980) studied this question.

synapsesocial.com/papers/6a86f29948ef9afcd2a250b7https://doi.org/10.1111/j.1748-1716.1980.tb06612.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Shortening velocity, active force and homogeneity of contraction during electrically evoked twitches in smooth muscle from rabbit urinary bladder1979 · 32 citations
  2. 2The Force‐Velocity Relation in Phasic Contractions of Venous Smooth Muscle1975 · 45 citations
  3. 3Isometric and Isotonic Length‐Tension Relations and Variations in Cell Length in Longitudinal Smooth Muscle from Rabbit Urinary Bladder1976 · 130 citations
  4. 4Tension responses to sudden length change in stimulated frog muscle fibres near slack length1977 · 859 citations
  5. 5Potassium accumulation in smooth muscle and associated ultrastructural changes1973 · 146 citations