November 1, 1989AJP Heart and Circulatory Physiology

Stimulus-specific changes in mechanical properties of vascular smooth muscle

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Population

Aortic smooth muscle strips

Comparison

Stimulation with phenylephrine vs Stimulation with KCl

Design

Preclinical

Authors

FBFrank V. BrozovichMayo Clinic in Arizona KMKathleen G. MorganVascular Medicine

Discussion

Member takes

Implication

Stimulus-specific Vmax dynamics in animal vessels are hypothesis-generating; leaves open relevance to human vasoconstriction or vasopressor selection.

Structured PICO

Population

Aortic smooth muscle strips

Intervention

Stimulation with phenylephrine

Comparator

Stimulation with KCl

Outcome

Mechanical properties including force, stiffness, and unloaded shortening velocity (Vmax)surrogate

Vascular smooth muscle exhibits stimulus-specific mechanical properties, with phenylephrine potentially inducing latch cross-bridges unlike KCl depolarization.

Cite This Study

Brozovich et al. (1989) studied this question.

synapsesocial.com/papers/6a88ed76c9c00c271ba2a237 https://doi.org/10.1152/ajpheart.1989.257.5.h1573

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Implication

Stimulus-specific Vmax dynamics in animal vessels are hypothesis-generating; leaves open relevance to human vasoconstriction or vasopressor selection.

Stimulus-specific changes in mechanical properties of vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Stimulus-specific changes in mechanical properties of vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider