Why the study?
Does combination therapy with triiodothyronine and carnitine improve myocardial dysfunction in streptozocin-diabetic rats?
Does combination therapy with triiodothyronine and carnitine improve myocardial dysfunction in streptozocin-diabetic rats?
Combination therapy targeting cardiac myosin ATPase and SR calcium uptake only partially rescues myocardial dysfunction in diabetic rats, highlighting the multifactorial nature of diabetic cardiomyopathy.
Partial rescue in diabetic rat hearts highlights multifactorial cardiomyopathy; hypothesis-generating for additional targets before clinical translation.
Streptozocin-diabetic rats were treated with a combination of triiodothyronine and carnitine for 6 weeks. These compounds were used as they are known to correct the diabetes-induced depression of cardiac myosin ATPase and sarcoplasmic reticular (SR) calcium uptake, respectively. Myocardial performance, which was assessed using the working heart preparation, revealed a depression of function in untreated diabetics when compared with controls at most left atrial filling pressures. Hearts from diabetic rats treated with the combination exhibited depression at only the higher filling pressures as compared with untreated or treated controls. The results suggest that functional alterations occurring as a result of diabetes cannot be accounted for by the depression of cardiac myosin ATPase and SR calcium uptake alone.
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Tahiliani et al. (1986) studied this question.
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