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January 19, 2006Cardiovascular DiabetologyOpen Access

Cardio-protective effects of carnitine in streptozotocin-induced diabetic rats

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Why the study?

Does oral carnitine supplementation normalize carnitine levels and cardiac function in streptozotocin-induced diabetic rats?

Population

72 male Wistar rats at 26 weeks of age.

Comparison

L-carnitine added to drinking water for 16 weeks. vs Streptozotocin-induced diabetic rats without…

Design

Preclinical

Follow-up

18 weeks

Authors

JMJohn I. MaloneWest Virginia UniversityDCDavid CuthbertsonUniversity of South FloridaMMMichael A. MaloneTidelands Health

Discussion

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Implication

Leaves open clinical translation of carnitine in diabetic cardiomyopathy; extends preclinical metabolic findings in rat models.

Key Points

  • This study aims to evaluate the impact of carnitine supplementation on cardiac function in streptozotocin-induced diabetic rats.
  • 48 Wistar rats were induced with diabetes via streptozotocin at 26 weeks of age.
  • Echocardiograms and serum analyses (HbA1c, carnitine, and free fatty acids) were performed over 18 weeks.
  • 15 STZ-D rats received oral carnitine supplements for 16 weeks.
  • Heart rates in STZ-D rats (290 +/- 19 bpm) were significantly lower than controls (324 +/- 20 bpm), p < 0.05.
  • After 4 weeks of carnitine, STZ-D rats' heart rates normalized to 94 +/- 9 bpm, similar to controls.
  • Left ventricular mass/body weight ratio in STZ-D rats decreased to 2.3 +/- 0.2 with carnitine, comparable to controls at 2.2 +/- 0.3, p < 0.05.

Structured PICO

Does oral carnitine supplementation normalize carnitine levels and cardiac function in streptozotocin-induced diabetic rats?

P
Population
72 male Wistar rats at 26 weeks of age (48 made hyperglycemic by streptozotocin injection, 24 normal controls).
I
Intervention
L-carnitine (1 mg/ml) added to drinking water for 16 weeks.
C
Comparator
Streptozotocin-induced diabetic rats without carnitine supplementation, and normal non-diabetic control rats.
O
Outcome
Serum carnitine levels, heart rate (resting and dobutamine stress), and left ventricular mass/body weight ratio (LVM/BW) at 18 weeks.surrogate

Oral carnitine supplementation in streptozotocin-induced diabetic rats normalizes serum carnitine, heart rate regulation, and left ventricular size, suggesting a metabolic mechanism for diabetic cardiac dysfunction.

Cite This Study

Malone et al. (2006) studied this question.

synapsesocial.com/papers/6a70ce3c31a3df8243290bafhttps://doi.org/10.1186/1475-2840-5-2

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A 13C-NMR Study of Glucose Oxidation in the Intact Functioning Rat Heart Following Diabetes-induced Cardiomyopathy1993 · 48 citations
  2. 2Baroreflex dysfunction in diabetes mellitus. I. Selective impairment of parasympathetic control of heart rate1994 · 62 citations
  3. 3Relationship between cardiovascular dysfunction and hyperglycemia in streptozotocin-induced diabetes in rats2004 · 62 citations
  4. 4Baroreflex and chemoreflex dysfunction in streptozotocin-diabetic rats1997 · 80 citations
  5. 5The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus1993 · 24,821 citations