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October 1, 1993Journal of Molecular and Cellular CardiologyOpen Access

A 13C-NMR Study of Glucose Oxidation in the Intact Functioning Rat Heart Following Diabetes-induced Cardiomyopathy

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Key result

Experimentally induced diabetes with streptozotocin profoundly inhibited glucose oxidation and depressed cardiac function in isolated perfused rat hearts.

Population

Isolated perfused rat hearts from rats with experimentally induced diabetes and untreated controls

Comparison

Perfusion with 11 mM [1-13C]glucose as… vs Hearts from untreated control rats

Design

Preclinical

Follow-up

up to 90 min

Authors

JCJohn C. ChathamHeart Failure & TransplantJFJohn R. ForderGeorgetown University

Discussion

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Overview

Suggests metabolic basis for diabetic cardiomyopathy; leaves open whether restoring glucose oxidation improves outcomes in patients.

Structured PICO

P
Population
Isolated perfused rat hearts from rats with experimentally induced diabetes (streptozotocin 65 mg/kg, i.v.) and untreated controls
I
Intervention
Perfusion with 11 mM [1-13C]glucose as substrate, with subsequent addition of insulin (0.05 U/ml) and dichloroacetate (2 mM)
C
Comparator
Hearts from untreated control rats
O
Outcome
Glucose metabolism (incorporation of label from [1-13C]glucose into lactate and glutamate) and contractile functionsurrogate

Experimentally induced diabetes profoundly inhibits glucose oxidation and depresses cardiac function in isolated rat hearts, consistent with decreased glucose transport and pyruvate dehydrogenase activity.

Cite This Study

Chatham et al. (1993) studied Diabetes-induced cardiomyopathy. Streptozotocin-induced diabetes vs. Untreated control rats was evaluated on Glucose metabolism and contractile function. Experimentally induced diabetes with streptozotocin profoundly inhibited glucose oxidation and depressed cardiac function in isolated perfused rat hearts.

synapsesocial.com/papers/6aa394f8e0a56e090ff42a2dhttps://doi.org/10.1006/jmcc.1993.1133

Topics

Cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between cardiac function and substrate oxidation in hearts of diabetic rats1997 · 54 citations
  2. 2Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes1999 · 56 citations
  3. 3The effect of diabetes on performance and metabolism of rat hearts.1980 · 254 citations
  4. 4The Effects of Acute and Chronic Diabetes on Myocardial Metabolism in Rats1984 · 90 citations
  5. 5Mitochondrial dysfunction observed in situ in cardiomyocytes of rats in experimental diabetes1992 · 91 citations