Why the study?
Does streptozotocin-induced diabetes alter cardiac glucose and fatty acid oxidation in spontaneously hypertensive rats compared to normotensive rats?
Does streptozotocin-induced diabetes alter cardiac glucose and fatty acid oxidation in spontaneously hypertensive rats compared to normotensive rats?
Exaggerated stimulation of fatty acid oxidation by diabetes in hypertrophic left ventricles may be a key contributor to premature mechanical dysfunction.
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May link enhanced fatty acid oxidation to accelerated dysfunction in diabetic hypertension; leaves open human translation and therapeutic targeting.
Christe et al. (1995) studied this question.
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