Why the study?
Does streptozotocin-induced diabetes mellitus intensify cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats?
Population
50 eighteen-month-old male spontaneously hypertensive rats (SHR)
Comparison
Streptozotocin-induced diabetes mellitus vs Control group receiving intraperitoneal…
Design
Preclinical
Follow-up
9 weeks
Authors
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These rat-model findings should not change clinical practice; leaves open whether oxidative stress drives systolic impairment in diabetic hypertension.
Does streptozotocin-induced diabetes mellitus intensify cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats?
Diabetes mellitus induces cardiac dilation, functional impairment, increases oxidative stress, and activates the fetal gene program in aged spontaneously hypertensive rats.
Rosa et al. (2013) studied this question.
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