Key result
Long-term experimental type 1 diabetes in rats is characterized by myocardial fibrosis and apoptosis, but lacks the myocardial inflammation seen in hypertension and short-term diabetes.
Population
Normotensive and spontaneously hypertensive rats (SHR), and cultured cardiomyocytes
Comparison
Streptozotocin injections to induce type 1… vs Vehicle injections (control rats)
Design
Preclinical
Follow-up
6 or 22 weeks
Authors
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Findings in rat T1D model suggest non-inflammatory fibrosis; requires confirmation in human studies before guiding therapy.
Long-term experimental type 1 diabetes induces myocardial fibrosis and apoptosis, but not inflammation, which is blunted by local anti-inflammatory and antioxidant molecules.
Ares-Carrasco et al. (2009) studied Type 1 diabetes mellitus and hypertension. Streptozotocin injections (DM1 induction) vs. Vehicle was evaluated on Myocardial damage (fibrosis, apoptosis, inflammation). Long-term experimental type 1 diabetes in rats is characterized by myocardial fibrosis and apoptosis, but lacks the myocardial inflammation seen in hypertension and short-term diabetes.
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