Key result
Angiotensin II-induced mild hypertension resulted in significantly more pronounced left ventricular hypertrophy in type 2 diabetic mice compared to non-diabetic controls (LV mass increase +51% vs +34%, p<0.01).
Why the study?
Does angiotensin II-induced hypertension aggravate cardiac hypertrophy and dysfunction in type 2 diabetic mice?
Does angiotensin II-induced hypertension aggravate cardiac hypertrophy and dysfunction in type 2 diabetic mice?
Absolute Event Rate: 51% vs 34%
p-value: p=<0.01
Type 2 diabetes in its early stages renders the heart more susceptible to hypertension-induced hypertrophic remodeling, even before overt diabetic cardiomyopathy develops.
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Early type 2 diabetes may heighten hypertrophic response to mild hypertension; leaves open translation to human disease or practice.
Bilsen et al. (2014) studied Type 2 diabetes and hypertension (n=41). Angiotensin II vs. Vehicle was evaluated on Increase in Left Ventricular (LV) mass (p=<0.01). Angiotensin II-induced mild hypertension resulted in significantly more pronounced left ventricular hypertrophy in type 2 diabetic mice compared to non-diabetic controls (LV mass increase +51% vs +34%, p<0.01).
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