What does this research mean for the field?

Systolic blood pressure is a consistent and independent predictor of fatal stroke risk across diverse demographic groups, including men, women, whites, and African Americans, and is superior to other blood pressure parameters for predicting stroke. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

Determine whether various blood pressure parameters, including systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure, predict the risk of fatal stroke across sexes and racial groups.

February 25, 2007American Journal of Hypertension

Blood Pressure Parameters and Risk of Fatal Stroke, NHANES II Mortality Study

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Why the study?

Does a 10 mm Hg increase in systolic blood pressure predict fatal stroke in adults across different demographic groups including women and African Americans?

Population

6,667 adults from the Second National Health and Nutrition Examination Survey Mortality Study

Design

Cohort

Follow-up

median of nearly 15 years

Authors

DBDevin L. BrownUniversity of Michigan WGWarwick GilesUniversity of Sheffield KGKurt J. GreenlundPreventive Cardiology

Discussion

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Implication

SBP predicts fatal stroke across sexes and races; extends observational data but leaves causal effects and practice change open.

Key Points

Determine whether various blood pressure parameters, including systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure, predict the risk of fatal stroke across sexes and racial groups.
Analyzed prospective cohort data from 6,667 adults (3,205 men and 3,462 women) participating in the Second National Health and Nutrition Examination Survey (NHANES II) Mortality Study.
Evaluated the relative risk of fatal stroke associated with a 10 mm Hg increase across four blood pressure parameters over a median follow-up of nearly 15 years.
Over the follow-up period, 113 fatal strokes occurred, comprising 62 events in men and 51 events in women.
Each 10 mm Hg increase in systolic blood pressure independently increased fatal stroke risk across all cohorts: men (RR = 1.19), women (RR = 1.15), White individuals (RR = 1.17), and African American individuals (RR = 1.28; all P ≤ .05).
Other blood pressure parameters showed inconsistent associations with mortality, and combining parameters did not improve fatal stroke risk prediction compared with systolic blood pressure alone.

Structured PICO

Does a 10 mm Hg increase in systolic blood pressure predict fatal stroke in adults across different demographic groups including women and African Americans?

Population

6,667 adults (3,205 men; 3,462 women) from the Second National Health and Nutrition Examination Survey (NHANES II) Mortality Study

Intervention

10 mm Hg increase in blood pressure parameters (systolic BP, diastolic BP, pulse pressure, and mean arterial pressure)

Outcome

Fatal strokehard clinical

Systolic blood pressure is a consistent and independent predictor of fatal stroke across both sexes and major racial groups, outperforming other blood pressure parameters.

Cite This Study

Brown et al. (2007) studied this question.

synapsesocial.com/papers/6a1d413a102421609405174d https://doi.org/10.1016/j.amjhyper.2006.08.004

Topics

Hypertension management

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Blood Pressure Parameters and Risk of Fatal Stroke, NHANES II Mortality Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Blood Pressure Parameters and Risk of Fatal Stroke, NHANES II Mortality Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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