Why the study?
Do diabetic patients with myocardial infarction have worse outcomes compared to nondiabetic patients?
Do diabetic patients with myocardial infarction have worse outcomes compared to nondiabetic patients?
Diabetes is associated with worse acute and long-term outcomes following myocardial infarction, highlighting the need for optimized management such as beta-blocker therapy.
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Diabetes-associated MI mortality gap persists; reinforces consensus risk stratification while leaving beta-blocker benefits open for RCTs.
It has long been thought that the symptomatology and prognosis of coronary events in patients with diabetes may differ from those in nondiabetic persons. A review of recent data demonstrates a higher mortality during the acute phase of myocardial infarction for diabetic patients than for their nondiabetic counterparts, possibly related to a higher incidence of congestive heart failure and cardiogenic shock. The clinical course of diabetic patients with infarction and the role of insulin in myocardial adaptation to ischemia are both reviewed. Diabetic patients surviving the acute phase of myocardial infarction have a lower survival in follow-up than nondiabetic survivors, although some improvement in survival has been noted following beta-adrenergic-blocker therapy.
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Dean J. Kereiakes (1985) studied this question.
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