Why the study?
Does autonomic nervous system modulation affect insulin secretion in normal subjects and patients with heart failure?
Population
13 normal subjects and 5 patients with heart failure (n=18)
Design
Other
Authors
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Autonomic modulation of insulin secretion in HF is hypothesis-generating; leaves open whether alpha-blockade or beta-stimulation confers metabolic benefit.
Does autonomic nervous system modulation affect insulin secretion in normal subjects and patients with heart failure?
Alpha-blockade and beta-stimulation increase insulin secretion, suggesting these agents may provide metabolic benefits in heart failure by counteracting sympathetic-induced insulin suppression.
Majid et al. (1970) studied this question.
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