What does this research mean for the field?

Both filamentous and nonfilamentous actin behave as viscoelastic solids with shear rate-dependent yield stresses when given sufficient time to equilibrate. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1985Journal of Biological ChemistryOpen Access

Mechanical properties of actin.

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Population

Actin purified by gel filtration from rabbit skeletal muscle and Acanthamoeba

Comparison

Evaluation of mechanical properties using a cone… vs Ovalbumin and cytochrome c

Design

Preclinical

Authors

MSMasahiko SatoPlanetary Science Institute GLG LeimbachJohns Hopkins University WSWolfgang H. SchwarzTechnical University of Munich

Discussion

Member takes

Implication

Actin viscoelastic properties warrant caution in cardiac cell models; extends biophysical data but leaves clinical translation open.

Structured PICO

Population

Actin purified by gel filtration from rabbit skeletal muscle and Acanthamoeba

Intervention

Evaluation of mechanical properties using a cone and plate rheometer over a wide range of oscillation frequencies and shear rates

Comparator

Ovalbumin and cytochrome c

Outcome

Mechanical properties (viscoelasticity, dynamic viscosity, dynamic elasticity, yield stress)

Actin, whether filamentous or nonfilamentous, behaves as a viscoelastic solid when given ample time to equilibrate.

Cite This Study

Sato et al. (1985) studied this question.

synapsesocial.com/papers/6a1d4ffd1024216094052c95 https://doi.org/10.1016/s0021-9258(17)39513-3

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Mechanical properties of actin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanical properties of actin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider