Key result
Intravenous iron therapy improves symptoms in heart failure, but current diagnostic criteria (ferritin <100 ng/mL or Tsat <20%) may misclassify up to 33% of patients as iron-deficient.
Why the study?
The exact pathophysiology, accurate definition, and true prevalence of iron deficiency in patients with heart failure remain unsettled.
Does intravenous iron therapy improve symptoms and functional capacity in patients with heart failure and iron deficiency?
Does intravenous iron therapy improve symptoms and functional capacity in patients with heart failure and iron deficiency?
Intravenous iron therapy improves symptoms and functional capacity in heart failure patients with iron deficiency, although the current serum-based definitions of iron deficiency in this population may not accurately reflect true bone marrow iron stores.
Answers are grounded in this paper and cite their sources.
Current iron deficiency criteria may warrant reevaluation in heart failure; leaves open optimal patient selection for intravenous iron.
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Ghafourian et al. (2019) conducted a review in Heart Failure with Iron Deficiency. Intravenous Iron Therapy vs. Oral iron or standard of care was evaluated. Intravenous iron therapy improves symptoms in heart failure, but current diagnostic criteria (ferritin <100 ng/mL or Tsat <20%) may misclassify up to 33% of patients as iron-deficient.
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