Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients
Why the study?
Do higher than expected endogenous erythropoietin levels predict increased mortality in anaemic patients with chronic heart failure?
Structured PICO
Do higher than expected endogenous erythropoietin levels predict increased mortality in anaemic patients with chronic heart failure?
P
Population
74 anaemic patients with chronic heart failure (CHF) from a cohort of 240 patients
I
Intervention
Endogenous erythropoietin (EPO) levels higher than expected (observed/predicted ratio > 1.09)
C
Comparator
Endogenous EPO levels as expected or lower than expected (observed/predicted ratio < 0.92)
O
Outcome
Mortality at median 4.9 years follow-uphard clinical
In anaemic patients with chronic heart failure, endogenous erythropoietin levels higher than expected are associated with increased mortality, suggesting EPO resistance.
Authors
Discussion
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Implication
Higher-than-expected EPO levels associated with mortality in anaemic HF; hypothesis-generating for EPO resistance, needs prospective confirmation.
Cite This Study
Meer et al. (2008) studied this question.