What question did this study set out to answer?

This research examines how regional adrenergic stimulation affects the synchrony of myocardial contraction in dogs.

September 1, 1986AJP Heart and Circulatory Physiology

Modulation of synchrony of left ventricular contraction by regional adrenergic stimulation in conscious dogs

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Why the study?

Does regional intracoronary injection of norepinephrine alter the synchrony of left ventricular contraction in conscious dogs?

Key Points

This research examines how regional adrenergic stimulation affects the synchrony of myocardial contraction in dogs.
Dogs were instrumented for left ventricular pressure and segment measurement in different myocardial regions.
Norepinephrine was injected into the circumflex artery in bolus doses to avoid systemic effects.
Measurements included percent segment shortening, shortening velocity, and left ventricular pressures before and after NE injection.
Intracoronary norepinephrine injection increased percent segment shortening and mean shortening velocity in the posterior segment.
Duration of shortening in the posterior segment was significantly reduced.
No changes were seen in the anterior segment, and left ventricular systolic pressure remained unchanged.

Structured PICO

Does regional intracoronary injection of norepinephrine alter the synchrony of left ventricular contraction in conscious dogs?

Population

Conscious dogs instrumented to measure left ventricular pressure and segment length

Intervention

Intracoronary injection of norepinephrine (NE) into the circumflex artery in bolus doses

Outcome

Percent segment shortening, mean shortening velocity, and duration of shortening in the posterior and anterior regions of the left ventriclesurrogate

Regional sympathetic stimulation via intracoronary norepinephrine alters left ventricular contraction synchrony in conscious dogs, suggesting localized sympathetic activation may affect mechanical performance.

Discussion

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Implication

Preclinical canine data warrant no clinical extrapolation; leaves open whether localized sympathetic activation influences human LV synchrony.

Cite This Study

Gwirtz et al. (1986) studied this question.

synapsesocial.com/papers/6a1d643932d43530c25da7ce https://doi.org/10.1152/ajpheart.1986.251.3.h490

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Implication

Preclinical canine data warrant no clinical extrapolation; leaves open whether localized sympathetic activation influences human LV synchrony.

Modulation of synchrony of left ventricular contraction by regional adrenergic stimulation in conscious dogs

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Modulation of synchrony of left ventricular contraction by regional adrenergic stimulation in conscious dogs

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider