Key result
The left ventricular apical myocardium demonstrated greater beta-adrenergic receptor density (455 vs 341 fmol/mg protein, p<0.05) and responsiveness to adenylate stimulation than the basal region.
Absolute Event Rate: 455% vs 341%
p-value: p=<0.05
Greater beta adrenergic receptor density and responsiveness to adenylate stimulation in the apical myocardium compensates for its sparse sympathetic innervation.
No takes yet. Share an insight, caveat, or question.
Apical hyper-responsiveness may explain regional vulnerability in stress cardiomyopathy; leaves open human relevance.
Mori et al. (1993) studied this question. Adrenergic stimuli (noradrenaline, forskolin derivative) vs. Basal myocardium was evaluated on Beta adrenergic receptor density and contractile/metabolic responses (p=<0.05). The left ventricular apical myocardium demonstrated greater beta-adrenergic receptor density (455 vs 341 fmol/mg protein, p<0.05) and responsiveness to adenylate stimulation than the basal region.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: