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June 30, 2004HepatologyOpen Access

Beyond insulin resistance in NASH: TNF-α or adiponectin?

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Why the study?

Are hypoadiponectinemia and TNF-alpha activation features of NASH, and do they correlate with histological severity in NAFLD?

Population

109 subjects with nonalcoholic fatty liver disease, including 80 with NASH and 29 with simple steatosis, and…

Design

Cross-sectional

Authors

JHJason M. HuiThe University of SydneyAHAlex HodgeUniversity of NottinghamGFGeoffrey C. FarrellAustralian National University

Discussion

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Implication

May mark NASH severity independent of insulin resistance; leaves open causal role and therapeutic targeting in NAFLD.

Structured PICO

Are hypoadiponectinemia and TNF-alpha activation features of NASH, and do they correlate with histological severity in NAFLD?

P
Population
109 subjects with nonalcoholic fatty liver disease (NAFLD), including 80 with NASH and 29 with simple steatosis, and controls matched by age, sex, and body mass index
C
Comparator
Controls matched by age, sex, and body mass index; and subjects with simple steatosis
O
Outcome
Serum levels of adiponectin, TNF-alpha, sTNFR2, leptin, and correlation with severity of histological changessurrogate

Hypoadiponectinemia is a feature of NASH independent of insulin resistance and is associated with more extensive necroinflammation.

Cite This Study

Hui et al. (2004) studied this question.

synapsesocial.com/papers/6a1d6e1b7328fa9a742f7dbdhttps://doi.org/10.1002/hep.20280
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Also Consider

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  1. 1Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia2001 · 3,447 citations
  2. 2Adiponectin, Metabolic Risk Factors, and Cardiovascular Events among Patients with End-Stage Renal Disease2002 · 763 citations
  3. 3Nonalcoholic Steatohepatitis: Definition and Pathology2001 · 919 citations
  4. 4Clinical and Histologic Spectrum of Nonalcoholic Fatty Liver Disease Associated With Normal Alt Values2003 · 1,208 citations
  5. 5Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.2000 · 2,486 citations