Key result
Definite NASH was significantly associated with elevated hs-CRP, decreased serum adiponectin, and a higher leptin/adiponectin ratio compared to patients without NASH (p<0.0001).
Why the study?
Low-grade inflammation is involved in NAFLD pathogeny and adipose tissue dysfunction contributes to metabolic disease, in the context of NASH posing risks for fibrosis and cirrhosis.
Cross-Sectional (n=68)
No
p-value: p=<0.0001
Systemic and adipose tissue inflammation markers, specifically hs-CRP and the leptin/adiponectin ratio, correlate significantly with the histological severity of non-alcoholic steatohepatitis (NASH).
May support noninvasive NASH assessment; leaves open whether markers predict progression or guide therapy.
INTRODUCTION: Non-alcoholic steatohepatitis (NASH) is a progressive form of liver steatosis that involves a risk of progression towards fibrosis, cirrhosis, and end-stage liver disease. Low-grade inflammation is recognized to be involved in non-alcoholic fatty liver disease (NAFLD) pathogeny. Additionally, adipose tissue dysfunction plays an important role in the development of metabolic diseases. PATIENTS, MATERIALS AND METHODS: We conducted a study on 68 patients with liver steatosis confirmed through liver biopsy during the surgery. In all the patients, we recorded anthropometric parameters and we performed blood tests for systemic inflammation [high-sensitivity C-reactive protein (hs-CRP), fibrinogen] and serum adipokines related to adipose tissue inflammation (leptin, adiponectin). Additional to histopathological examination, we also performed the immunohistochemical study of inflammatory mononuclear cells. RESULTS: The 68 patients had a mean age of 56.57±4.94 years old, had a mean value of hs-CRP of 2.30±0.91 mg∕L, a mean value of leptin of 14.02±17.02 ng∕mL and a mean value of adiponectin of 7.54±0.38 mg∕L. In all the cases studied by liver biopsy, the steatosis exceeded 5% of hepatocytes, but the frequency of NASH was 26.47%. Cluster of differentiation (CD)45-positive, CD4-positive, and CD8-positive T-lymphocytes predominated in the studied cases. We obtained a statistically significant high association between definite NASH and the values of hs-CRP, serum adiponectin and leptin∕adiponectin ratio (p<0.0001). CONCLUSIONS: Systemic and adipose tissue inflammation was statistically significant associated with histological lesions of steatosis and NASH, suggesting that the determination of hs-CRP and serum adipokines in dynamics in patients with NAFLD is predictive for the progression of the disease.
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A 2022 study conducted a cross-sectional in Non-alcoholic steatohepatitis (NASH) (n=68). Systemic and adipose tissue inflammation markers (hs-CRP, adiponectin, leptin) vs. Patients without definite NASH was evaluated on Association between definite NASH (NAFLD activity score ≥5) and values of hs-CRP, serum adiponectin, and leptin/adiponectin ratio (p=<0.0001). Definite NASH was significantly associated with elevated hs-CRP, decreased serum adiponectin, and a higher leptin/adiponectin ratio compared to patients without NASH (p<0.0001).
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