Key result
Uniaxial extension testing of human carotid plaques showed that media and fibrous cap are stiffer than lipid or intraplaque haemorrhage (median Young's modulus at λ=1: 290.1, 244.5 vs 104.4, 52.9 kPa).
The study provides specific material constants for different components of human carotid atherosclerotic plaques, demonstrating that media and fibrous cap are stiffer than lipid and intraplaque hemorrhage/thrombus, which can inform computational modeling of plaque vulnerability.
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Supplies constitutive parameters for plaque modeling; leaves open clinical validation before influencing rupture risk assessment.
Teng et al. (2014) studied Carotid atherosclerotic plaques (n=21). Uniaxial extension testing was evaluated on Incremental Young's modulus at various stretch ratios. Uniaxial extension testing of human carotid plaques showed that media and fibrous cap are stiffer than lipid or intraplaque haemorrhage (median Young's modulus at λ=1: 290.1, 244.5 vs 104.4, 52.9 kPa).
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