What does this research mean for the field?

Mechanical strain increases brain natriuretic peptide (BNP) gene expression in cardiac myocytes via a transcriptional mechanism mediated by MAPK and JNK signaling pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

October 1, 1997Journal of Biological ChemistryOpen Access

Mechanical Strain Increases Expression of the Brain Natriuretic Peptide Gene in Rat Cardiac Myocytes

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Why the study?

Does mechanical strain increase BNP gene expression in rat cardiac myocytes?

Structured PICO

Does mechanical strain increase BNP gene expression in rat cardiac myocytes?

Population

Rat ventricular cardiocytes cultured on collagen-coated silicone elastomer surfaces

Intervention

Cyclical mechanical strain (1 Hz)

Comparator

Control cells (unstrained)

Outcome

Brain natriuretic peptide (BNP) secretion, BNP mRNA levels, and expression of a transiently transfected -1595 human BNP-luciferase reportersurrogate

Mechanical strain increases myocardial BNP gene expression through a transcriptional mechanism involving MAPK and JNK pathways.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Animal data leave human translation open; extends mechanistic BNP research to MAPK/JNK pathways in vitro.

Cite This Study

Liang et al. (1997) studied this question.

synapsesocial.com/papers/6a1d6fdb5b7fddc35205487b https://doi.org/10.1074/jbc.272.44.28050

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Mechanical Strain Increases Expression of the Brain Natriuretic Peptide Gene in Rat Cardiac Myocytes

Structured PICO

Discussion

Implication

Cite This Study

Mechanical Strain Increases Expression of the Brain Natriuretic Peptide Gene in Rat Cardiac Myocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider