Key result
Novel endo-epicardial bipolar RF ablation prototype achieves 100% transmural lesions in preclinical testing.
Why the study?
The study was designed to test in vivo a new prototype for radiofrequency ablation using an endo-epicardial biparietal bipolar magnetic coupling system.
This proof-of-concept study demonstrates the feasibility of a novel magnetic-coupled biparietal bipolar RF ablation system to create consistent transmural lesions.
Should not change clinical practice; hypothesis-generating for biparietal bipolar RF systems and requires human validation.
Background To test in vivo a new design prototype for radio frequency (RF) ablation. Methods A prototype based on a concept of endo‐epicardial biparietal bipolar RF ablation with the atrial tissue interposed and consisting of two specular endocardial‐epicardial catheters was tested in four pigs (80±5 kg ) . The endocardial catheter was introduced into the left atrium through the left atrial appendage on the beating heart. The epicardial counterpart was placed manually on the atrial epicardial surface. The coupling of the two catheters was achieved using a neodymium magnet around the gold plate electrode, and RF was applied to the interposed tissue. The hearts were excised, and the lesions were examined using morphometric evaluation. Results The RF application resulted in transmural lesions in all of the four animals tested. In these animals the maximum endocardial width (W endo ) was 6.34 ± 0.25, 6.54 ± 0.33, 6.36 ± 0.57, and 6.49 ± 0.96 mm. The pericardial width (W epi ) was similar: 6.37 ± 0.47, 6.58 ± 0.32, 6.35 ± 0.56 and 6.53 ± 0.94 mm. The lesion area was 924.78, 949.25, 944.25, and 926.05 mm 2 , and the lesion volume was 92.47, 94.92, 94.42, and 92.60 mm 3 , respectively. Conclusions The idea of an endocardial‐epicardial bidirectional biparietal bipolar radiofrequency tool such that the atrial tissue is fully interposed between the two RF poles might be promising for future clinical applications. Further research is warranted.
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Matteucci et al. (2021) studied Healthy pigs (preclinical model) (n=4). Endo-epicardial biparietal bidirectional bipolar radiofrequency ablation prototype was evaluated on Transmurality of lesions. The novel endo-epicardial biparietal bidirectional bipolar radiofrequency ablation prototype achieved 100% transmural lesions in all tested animals.
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