Key result
Biparietal bipolar radiofrequency ablation catheter prototype achieves 100% transmurality in ex vivo porcine atria.
Why the study?
The study was designed to evaluate the size and depth of linear lesions using a custom-made radiofrequency biparietal bipolar ablation catheter in an in vitro, single-stage setting.
Does a custom-made radio frequency biparietal bipolar ablation catheter create effective linear lesions in an ex vivo pig model?
Does a custom-made radio frequency biparietal bipolar ablation catheter create effective linear lesions in an ex vivo pig model?
A novel biparietal bipolar radiofrequency catheter prototype successfully created transmural linear lesions in an ex vivo pig model, showing promise for hybrid atrial fibrillation ablation.
Hypothesis-generating for AF ablation catheter design; requires in vivo and clinical validation before any practice consideration.
Objective To evaluate the size and depth of linear lesions by in vitro testing with a custom-made radio frequency biparietal bipolar ablation catheter in a single-stage setting. Methods A custom-made catheter was created to generate linear lesions around the left atrium and pulmonary veins of an ex vivo pig. Two frames were made, 1 epicardial and 1 endocardial. A continuous copper braid electrode and an alignment system consisting of 2 parallel rows of neodymium magnets were embedded in a flexible plastic support. After 24 hours of formalin conservation, samples of the left atrium of a freshly slaughtered pig were sliced in a cryotome, thus obtaining a sequence of 100-µm thick layers extending from the endocardial to the epicardial side. After being digitized through a scanner, these layers were evaluated using morphometric computer software. For each slice, we evaluated the maximum length of the lesions, the maximum epicardial length, the maximum endocardial length, the total area of the lesion, and the total volume. Results Forty transmural lesions from 40 specimens were obtained. The results were the following (the number in parenthesis is the interquartile range in mm): lesion maximum length ( L MAX ) was 7.297 mm (0.006), epicardial maximum length ( L EPI ) was 7.291 mm (0.014), and endocardial maximum length was 7.291 mm (0.018). The total area and total volume were 1018.50 ± 36.51 mm 2 and 101.85 ± 3.65 mm 3 , respectively. Conclusions Our prototype showed very promising results. The next step will be to enhance the design for clinical application.
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Matteucci et al. (2021) studied Atrial fibrillation (in vitro model) (n=40). Biparietal bipolar radiofrequency ablation catheter prototype was evaluated on Transmurality of linear lesions. In vitro testing of a new biparietal bipolar radiofrequency ablation catheter prototype on ex vivo porcine left atria achieved 100% transmurality of linear lesions.
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