Key result
Cardiothoracic ratio of 0.42 to 0.49 is linked to ~45% higher all-cause mortality.
Why the study?
Does a cardiothoracic ratio in the upper normal range (0.42-0.49) predict increased mortality in patients undergoing coronary angiography compared to a lower ratio (<0.42)?
Cohort (n=1,005)
Yes
Does a cardiothoracic ratio in the upper normal range (0.42-0.49) predict increased mortality in patients undergoing coronary angiography compared to a lower ratio (<0.42)?
Hazard Ratio: 1.45 (95% CI 1.03–2.05)
Absolute Event Rate: 27.8% vs 18.9%
p-value: p=<0.001
A cardiothoracic ratio conventionally considered normal (0.42-0.49) independently predicts higher mortality in patients with coronary disease, challenging the traditional >0.5 cut-off.
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May challenge conventional cardiothoracic ratio threshold in coronary disease; leaves open causality and need for prospective validation.
Justin et al. (2006) conducted a cohort in Patients undergoing coronary angiography (n=1,005). Cardiothoracic ratio 0.42-0.49 vs. Cardiothoracic ratio <0.42 was evaluated on All-cause mortality (adjusted HR 1.45, 95% CI 1.03 to 2.05, p=<0.001). A cardiothoracic ratio between 0.42 and 0.49 was associated with a 45% increased risk of all-cause mortality compared to a ratio below 0.42 (adjusted HR 1.45).
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