What does this research mean for the field?

Urinary outputs of norepinephrine and its major metabolites (normetanephrine, 3-methoxy-4-hydroxyphenylglycol, and vanillylmandelic acid) are highly intercorrelated in both unipolar depressed patients and normal controls. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

February 1, 1988Archives of General Psychiatry

High Intercorrelations Among Urinary Outputs of Norepinephrine and Its Major Metabolites

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Population

52 subjects, comprising unipolar depressed patients (n = 28) and normal controls (n = 24).

Design

Cross-sectional

Authors

ARAlec RoyUniversity of Minnesota

Discussion

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Implication

Supports replicated norepinephrine metabolite correlations in depression; leaves open biomarker utility pending prospective validation.

Structured PICO

Population

52 subjects, comprising unipolar depressed patients (n = 28) and normal controls (n = 24).

Comparator

Normal controls (n = 24)

Outcome

Intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites (normetanephrine [NM], 3-methoxy-4-hydroxyphenylglycol [MHPG], and vanillylmandelic acid [VMA])surrogate

The study replicates previous findings of strong intercorrelations among urinary outputs of norepinephrine and its major metabolites in depressed patients.

Cite This Study

Alec Roy (1988) studied this question.

synapsesocial.com/papers/6a1d8ae27328fa9a742fa75b https://doi.org/10.1001/archpsyc.1988.01800260072009

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High Intercorrelations Among Urinary Outputs of Norepinephrine and Its Major Metabolites

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High Intercorrelations Among Urinary Outputs of Norepinephrine and Its Major Metabolites

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider