Why the study?
Does Moclobemide reduce urinary norepinephrine excretion in patients with major depressive disorders?
Population
26 patients diagnosed with major depressive disorders (primary, unipolar)
Comparison
Moclobemide (Ro 11-1163) for 14 days vs Control population (for baseline comparison)
Design
Cohort
Follow-up
14 days
Authors
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May link moclobemide to reduced norepinephrine in depression; hypothesis-generating and should not yet alter practice.
Does Moclobemide reduce urinary norepinephrine excretion in patients with major depressive disorders?
Moclobemide treatment significantly decreases urinary norepinephrine excretion and improves depression scores in patients with major depressive disorders.
Dajas et al. (1984) studied this question.
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